Fat Burning Anti Aging Kitchen
Researchers have efficiently increased the lifespan of animals as well as there are first researches which describe how we might turn around aging. So how could we one day rever aging?
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In the 70s, researchers observed that cells just grow for a restricted quantity of days busy (Hayflick limitation). For many years, so-called characteristics old have been revealed. These trademarks of aging govern exactly how our cells age and we could try to slow down dem to "reverse aging".
The initial trademark of aging is anomaly. We can obtain mutations by being exposed to UV radiation or certain chemicals or via cellular division. Cell divsion likewise causes a second characteristic of aging (telomere attrition). Additionally, our mitochondria start to function much less as top quality checks do not work appropriately anymore.
The hallmarks of aging are firmly connected to epigenetics. Epigenetics suggests that we have devices (DNA methylation, histone alterations) which control the task of genes. Epigenetics controls the development of embryonic stem cells into cells of our body but likewise influence aging. The loss of mitochondria for example is connected to useless epigenetic layers. As we age, a minimum of three epigenetic modifications namely H4K16 acetylation, H3K4 trimethylation, or H4K20 trimethylation acumulate. Things is that epigenetics is reversible … so can we additionally reverse aging?
Diets have been revealed to decrease (and also turn around aging to a tiny degree). Cells also reveal less damages in their DNA as well as we discover greater levels of proteins which are located in "young cells". The activity of mitochondria is also increased if we undergo calorie restriction. Diets likewise affect the manufacturing of sirtuins which enhance the life expectancy and reverse aging. Various compounts (such as NMN as well as remodelin) have been shown to boost the epigenetic landscape which might have an effect on reversing aging. Workout also may aid to turn around aging as it helps to increase the activity of mitochondria. Reflection and having less anxiety also assists to boost the sizes of telomeres which could assist to reverse aging. In conclusion research studies suggests that some characteristics of aging can be reversed so lets see where that goes!
0:00 -0:46 Intro
0:46 -3:53 Characteristics of Aging
3:53 -6:38 Epigenetics Controls Genetics
6:38 -8:45 Turning around Aging: what is known
8:45 -11:25 Reversing Aging through Diets & Sports
11:25 -12:13 My Opinion
References:
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Some images were originated from Servier Medical Art by Servier. You can locate over 3000 complimentary clinical photos below:
Infected cells by Beach front, CC BY 3.0
Drosophila by Kersti Nebelsiek, CC BY 3.0
Hayflick restriction by Azmistowski17, CC BY 4.0
Conrad Waddington by, CC BY 4.0
Breast tissue necrosis by Calicut Medical University, CC BY 4.0
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Genre as well as Mood: Hip Jump & Rap + Brilliant.
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About Clemens Steinek:.
CLEMENS STEINEK is a PhD student/youtuber (LifeLabLearner) who is currently conducting stem cell research study in Germany.
There needs to be an Apollo Program/Manhattan Project level crash program to develop life extension technology. Though first I suspect we are going to have to force society to view aging as a problem in the first place. You can’t solve anything if you can’t identify and define the problem.
Great video! Keep the high quality content coming!
It’s the ideology. If people in general don’t have an immortalist ideology then trying to seriously reverse human aging will not happen (to put it another way progress will be snail slow). A readily available example to this is the Apollo space program with human astronauts on the moon. No matter how good and beneficial such human activity is (on paper at least) if a whole lot of people don’t like doing that then it ain’t happening. Another example is religions if a lot of people like a particular religion and therefore a particular god(s) then it is happening it becomes popular and mainstream and here to stay.
If society becomes immortalist then a lot of institutions of society will have to change with it.
Education has to change in order to reflect immortalist ideals. Religions will have to be heavily edited and brought at the very least up to 21st century materialistic standards (ie a sentient green blob alien from the sombrero galaxy could be eligible to become Pope of Rome or woman as equal to man in the Muslim religion…there is also gender fluidity so a lot of things to discuss in order to make changes and so on). So all this hinges on “if” people in general would like doing and participating in this (unless it is forced and then obviously dystopic).
For human beings “world building” is summed up with creating children as per evolutionary mandate. While some thinking (ie to color a coloring book and you can choose any color) is required in order to accomplish that it’s basically the brain on autopilot. Immortality asks more from the brain since it has to imagine an immortalist future (it’s pros and cons) in the first place.
It is also kind of a paradox. If both rich and poor the king and beggar becomes immortal all of a sudden then would they still retain their social status? There are of course counter arguments against immortalism/immortality but those usually end up arguing that death (for the human animal) is somehow/someway a good thing. I personally think that the good things outweigh all the bad things so why not just do it?
“We do not want to genetically modify ourself…” yes we do, at least some. If you have a chronic genetic disease you become quite more tolerant of that thought.
Are you familiar with a compound called Resveratrol? Its been shown to activate Sirtuin1 and there are some interesting trials regarding longevity in model organisms. Sadly there are no large scale human trials yet and the overall situation regarding high quality studies is more like meeh…
Since we seem to only be able to reduce aging, but not prevent death entirely, I wonder how dying by old age will be like for people who have reduced aging.
Will it just be the same as we know it, but just moved later on in time? Will death by old age be more comfortable for people who have reduced aging? Or will it feel the same as normal deaths by old age?
Good video. I’m probably in the minority, but I would absolutely let myself be genetically modified to reverse my aging. I’d be first in line for that clinical trial.
No drug or procedure comes without side effects or consequences.
At a molecular level slightly altering any balanced system causes downstream and upstream changes to other adjacent systems. Putting a finger in the processes responsible for cell senescence will most likely result in another problem. This could manifest at the organ level all the way down to small molecular systems responsible for tasks like receptor recycling.
The hopeful minds funding this research like Peter Thiel are probably over optimistic about the likely hood of finding a cut and dry solution within the next 100 years. As for the perspective of laboratory scientist who have spent years working on cancers and other molecular processes, they’re much more skeptical that any immediate solution is on the horizon. I know this because it’s what I’ve spent a portion of my career working on.
@Erik Mccauley True, but the fact that fixing old problems often breeds new problems has never stopped us from going through with the fixing of those old problems. Whatever issues arise from the medical forestalling of aging, we can address them as they are discovered and come up with solutions which will, in turn, fix those new problems too.
Definitely an interesting topic.
Not to get the chance to follow science (and Sciencerely) longer and see all the fancy stuff from 2100 but also to reduce the chronic pain in the later part of our lives.
So yeah, wouldn’t mind if you dig deeper into this topic 🙂
I originally had Resveratrol in my script but decided to leave it out since (similar to your opinion) I also felt that the effects of specific anti-aging compounds in humans are largely unknown. To be fair such trials are extremely expensive as they would have to take years and there is a good chance that you lose many participants over time but it would be so interesting to know if they really a positive effect on lifespan!
Dang I really hope they bring this to market in the next 25 years.
Your channel rocks! Great quality videos. 🙂 Thanks
Well done. This presentation was not too dumbed down, yet not so overly comprehensive as to be too complicated to understand. I would be interested in another video like this that takes just a little deeper of a dive into the subject. This information has been offered many times on YouTube. I can’t stand to watch the scientist who gets into concepts that require a graduate degree in order to understand. However, I would like to understand more.
@MrGriff305 You may have a good point.
Human beings are not so good at balancing their animal and intellectual natures. In the case with immortalism what needs to be the norm is that our intellectual nature has to have primacy over our primal (primate) nature. For instance you will be able to think (cognize) to yourself to wait to have children until say when you are 200 yrs old instead of just giving into an instinct built around a limited lifespan.
FYI I’m also thinking within limited and conservative terms here.Sure you could just GATTACA the world and create a bunch of Ubermench humans however we still don’t have the.. finesse (and possibly into the far flung future as well) in order to not mess things up catastrophically when dealing with DNA and for other similar genetic code based life forms. There are different paths to immortality so this should not be viewed as some set back. Cryonics (a tech work in progress), Mind upload to digital cloud (terra incognita probably requires for us to find out how the “mind” works) and good ol’ cyborgs (plus more that I may have missed). I’ll take the clunky old fashioned immortality.
Later on (since everyone will still be around)
with the help of technology having lots of progeny won’t really matter (unless in extreme cases where you wan’t to have say 20+ children). Also Laws would definitely have to come into play and DNA based organic reproduction to be heavily regulated since the same tech will make it easier to have children (ie creating your own soccer team or private army of clones). In a deathist world that we find ourselves in all that do not matter yet because of death itself. The “exit” (one could argue that it’s an easy exit) that death offers will be less readily available. However on the upside there will be more of transparency and accountability.
I really enjoy all of your content, please keep it up!
The mainstream media needs to get on board with this anti-aging research. Too many people are conditioned to think aging is natural and barely anyone notice it.
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Great video sir. I agree with the end part of the video I could see us all probably extending our lifespan like even pass 100 but as for stop aging entirely I don’t see that happening. Especially since we all know that nothing last forever in this whole planet yet alone our universe. I think I’m fine with living even with aging, it’s a part of life.
Reverse aging doesn’t mean pure immortality. The word immortality is sometimes used as an exaggeration and a saying, used in a way of saying you have an extended and very long life. Not that you can’t die in an accident or something.
People who say they don’t want to live forever should still support this because you can always change your mind later but not if you’re already dead. I have been saying this… longevity is our choice! If we want to sustain our health, we have to do something about it! This will start by knowing what supplies our body needs. Start by eating a balanced diet, quit vices, exercise regularly and take an NMN supplement. Mine is a 500mg per day, NMN by Vitruvin Nutrition. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it’s possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. See your result and tell the same experience.
Wow, great video! I always wondered why I look so much younger than I am. No one in my age group looks as young and I don’t have the health problems they do. Everything you said made me realize why. So I don’t just look younger my cells really are younger! That’s the best news I had all day! I will keep doing what I’m doing and live a really long time! Hopefully. 💗
Great video. Please elaborate on the study on mice. I read that before and it was fascinating
I’m 28 years old, growing up as a kid I always wanted to learn why we age and why my parents got old and weak. Now I’m starting to see myself get older and it’s not nice to know that I’m no longer 21 where I didn’t care about aging or anything. I researched it all my life and would love to become a professor and help young people becomes graduates in biological science. The more people want to work to eliminate disease the higher chances we will be able to achieve it. I don’t want to die at 70 it’s early I believe time goes quick and we age quick
Do you have a PHD?
If you do then you can become a professor.
Cope
Its not hard to believe, I just turn thirty but I don’t feel or look any different when I was 19. Plus thanks to science, the human lifespan already increase during the last century.
Maybe in our next life, our life span may reach 150
@RuffleMUTT Not necessarily. The average lifespan by death age has not gone up. Years ago many infants died at birth children as did their mothers and there were many childhood deaths too mainly due to diseases. This lowered the overall numbers drastically.
Thankfully we are not coming back here to do this again. There’s an eternity awaiting and it’ll either be incredible or more terrible that you possibly could imagine. All depends on where you put your faith.
yes i myself would consider telomere studies
@ZZ where in the world does it say it defies nature?
same
Sign me up
Mutual feeling
@Path Wars I don’t have a PHD at the moment brother. But I love this topic so much that I will not fail once I start my studies. I am hoping to travel to America in the future to learn more about it. I so wish my dream will come true and we will find a cure. See you in 2077 ❤️
@Dog look into Ehlers-Danlos syndrom, alot of people have it without knowing it. I was one of them.
@lucky chicken gravity
@Pater Dionisios escape velocity
If it become available the rich will happily jump in line to separate themselves from the poors.
@CubaHubbaBubba I really hope you get to do all of that, especially bc it could help a lot of ppl. It. Hopefully it is accessible to ppl who need it.
@lucky chicken reversing aging does not go against the laws of nature. Sure, it’d require energy to go against increasing entropy and a lot of factors would need to be addressed (messing with a couple mechanisms would cause a change in others), but it’s not impossible.
Ok, I must admit those scientists begin to sound like our parents. They must of knew what those scientist have discovered.
thanks for your insights, very interesting and i am sure ur channel will do well with ur great content topics! <3
No the majority have to go. Average IQ is to slow and the population is to high.
Yeah I’m all for genetic modification. I don’t see what’s wrong with it.
I’m now 35 and I have always wondered as a kid what the point of life was if we just die anyway. Seems more things would get done if we lived indefinitely. No worries about getting old and dying would be great. Maybe our minds would focus on fixing other issues and create a legitimate heaven on earth.
I’m a transhumanist so I very much look at the body like a meat machine and genetic modification or cybernetic enhancements as upgrading it so it works better.
I really don’t understand the romantization of the human body as if we are somehow special and have to remain pure or something.
Anyway point is, put me on that list lfg
What terrifies me the most is not death, but rather getting old – the diseases, immobility, lack of autonomy… I swear if it wasn’t so against my sense of preservation, I would just end it once I start seeing the age getting in my way 😅
Yeah, there are some obvious moral limits to genetic research, other limits are more vague, and yet others are just a grey area rather than limits. I feel like sometimes we let our appeal to nature – which is a logical fallacy in other contexts – get in the way of improving our and others’ lives. The nature doesn’t care about humans and what they do; we are a product of nature, a part of it, and if we succeed at our grandest ambitions, it’s a win for nature too.
With that said, genetics has a profound problem – it’s really complex and evne minor changes can cause extreme harm. Until we overcome this barrier of uncertainty of outcome, caution is our ally.
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