Dr. Natalie Crawford: Female Hormone Health, Fertility & Vitality

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In this episode, my visitor is Natalie Crawford, MD, a dual board-certified medical professional focusing on obstetrics and gynecology, fertility and reproductive wellness and host of the "As a Woman" podcast. We review female hormonal agents, nutrition, supplementation, reproductive health, and fertility, consisting of exactly how the timing and period of adolescence effect a female's long-lasting hormonal agent cycles and menopause. We likewise talk about the pros and cons of numerous contraception approaches and exactly how hormone vs. non-hormonal birth control each influences fertility. We cover the factors that influence egg and sperm top quality and exactly how to take advantage of timing for fertilization. We also talk about treatments to evaluate women fertility, including egg matter and hormone screening, the procedure of egg cold, artificial insemination fertilizing (IVF) and various other reproductive options. This episode represents rather detailed insurance coverage of women hormonal agents and reproductive wellness, highlighting crucial tests and screening, behavior, dietary, supplement and prescription-based tools that females of any age can use to enhance their fertility, hormonal agent feature and total health.

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Oral contraceptive pill use in ladies adjustments preferences for male face manliness and is related to partner facial manliness:
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Timestamps
00:00:00 Dr. Natalie Crawford
00:01:40 Sponsors: Maui Nui Venison & Helix Sleep; The Brain Body Agreement
00:04:59 Women Adolescence & Development Characteristics, Height
00:13:27 Eggs & Ovulation, Harvesting Eggs, Artificial Insemination Fertilizing (IVF).
00:17:31 Endocrine Disruptors, Fetal Advancement.
00:21:39 Lavender, Tea Tree & Night Primrose Oils, Aromas, Diapers.
00:25:13 Bust Milk vs. Solution & Fertility.
00:26:04 Menstruation Cycle & Hormonal Agents, Timing.
00:34:08 Enroller: AG1.
00:35:59 Estrogen, Progesterone & Menstruation.
00:38:08 Hormonal Birth Control & Ovarian Reserve, AMH Screening, Fertility.
00:42:42 Spermatogenesis & Testosterone; Warmth: Ovaries vs Testes.
00:46:11 Period & Pregnancy, Conception Window.
00:48:56 Estrogen, Libido & Ovulation; Mittelschmerz.
00:51:33 Device: Intercourse Timing & Fertilization; Artificial Insemination, IVF.
00:55:03 Egg/Sperm Top Quality, Cigarettes, Vaping, Cannabis & Alcohol.
01:02:20 Sponsor: InsideTracker.
01:03:29 Intrauterine Device (IUD), Depo-Provera & Fertility.
01:10:00 Birth Control Threats & Advantages, Cancers Cells, Polycystic Ovarian Disorder (PCOS).
01:19:39 Blood Clot & Contraceptive Pill; Wellness Testing.
01:24:50 Tool: AMH Testing, Ovarian Reserve, Antral Hair Follicle Count Ultrasound.
01:29:55 IVF, In Vitro Growth (IVM); Very Early Ovarian Book Screening.
01:35:40 Tools: Egg Cold, IVF; Age & Egg Top Quality.
01:43:37 Egg Cold & IVF Treatments, Maternal Age, Success Fees.
01:51:30 Tool: Sperm Cold & Concerned Age, Vasectomy.
01:55:01 Hormones, Egg Cold & IVF.
02:00:42 Three-Parent IVF, Mitochondrial DNA.
02:05:21 IVF Embryo Storage Space & Contribution; Contributor Education & Consent.
02:14:29 Autism, Developmental Disorders, IVF Infants, Age.
02:20:36 Devices: Rest, Nutrition & Fertility; Dietary Fat.
02:27:32 Healthy protein, Meat, Tofu, Fish; Sugar, Artificial Sweeteners; Weight & Miscarriage.
02:37:38 Devices: Supplements; Prenatal Vitamins, Omega 3s, Vitamin D, Coenzyme Q10.
02:42:26 L-Carnitine & Male Fertility; PCOS & Myo-inositol; Metformin.
02:47:11 Egg Retrieval, Ovarian Hyperstimulation Disorder, Very Little Excitement.
02:57:56 INVOcell.
03:03:12 Egg Cold, Intracytoplasmic Sperm Injection (ICSI), Sperm Fragmentation.
03:11:45 Genetic Screening, IVF Transfer & Success Price, Embryo Banking.
03:15:10 Menopause.
03:19:47 Hormonal Agent Substitute Treatment & Menopause.
03:22:25 Early-signs of Menopause.
03:25:18 Zero-Cost Assistance, Spotify & Apple Reviews, Enrollers, YouTube Comments, Momentous, Social Network, Neural Network E-newsletter.

#HubermanLab #HormoneHealth #Fertility.

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51 thoughts on “Dr. Natalie Crawford: Female Hormone Health, Fertility & Vitality

  1. It’s gotten that far for me, that my girlfriend has given me a cup that says “What would Huberman do?” with an image of a brain on it for my birthday! Also I’m much fitter and healthier than a year ago. I hope this one will interest her as well! Cheers and thanks!

  2. I love Dr. Natalie Crawford!!! She was so encouraging to watch during our infertility journey, and now during our pregnancy journey ❤

  3. Wow! I was not expecting to be so enthralled by this episode. Only 30 minutes in and have already learned so much. Thank you ❤️

  4. 06:27 🌱 Female fetuses have the most eggs at 20 weeks gestation, losing over half before birth. Puberty triggers the release of eggs from the ovarian vault.
    11:30 📉 Girls experiencing early puberty may have a shorter adult height due to early closure of growth plates.
    15:23 🥚 Harvesting eggs for IVF or freezing does not reduce the total number of eggs or impact future fertility; it’s about accessing and preserving existing ones.
    19:09 🚸 Exposure to substances like evening primrose oil can lead to early secondary sex characteristics, but it’s not the initiation of puberty.
    20:45 🤰 Fetal development susceptibility to reproductive issues is influenced by the mother’s exposure during pregnancy, with the ’80s and ’90s showing potential negative impacts.
    22:34 🌿 Regular exposure to chemicals or toxins is unavoidable, but choosing unscented products, especially for children, is important to minimize lifetime exposure.
    23:03 🍼 Choices like laundry detergent, shampoo, and soaps can impact exposure to toxins; using products with fewer chemicals is recommended.
    24:42 🚼 The debate between cloth diapers and non-cloth diapers isn’t necessarily about permeability but rather personal preference; attention to toxins in diaper materials is crucial.
    25:24 🤱 Breastfeeding for the first six months contributes to immune system development; while it may not guarantee fertility, it correlates with protection against certain diseases.
    26:46 🩸 Menstrual cycle duration varies; it starts with the first day of bleeding. The luteal phase is relatively fixed at 12-14 days, and regular cycles should be less than 35 days apart.
    33:00 🔄 Irregular menstrual cycles, especially with decreasing length, might indicate changes in ovarian reserve, prompting concern about potential fertility issues.
    39:08 🩹 Combined oral contraception (the pill) does not change the release of eggs from the ovarian vault; it suppresses ovulation without impacting the total number of eggs.
    41:26 🌐 Prolonged use of birth control pills may temporarily suppress AMH levels, affecting ovarian reserve assessment; discontinuing use can reverse this effect.
    42:49 ♂ Testosterone supplementation in males halts testosterone and sperm production, unlike estrogen-based birth control in females, as spermatogenesis is a continuous process.
    43:58 🚹 Testosterone and sperm production are interconnected; prolonged testosterone use may impact sperm production, and 25% may not recover.
    46:16 🔄 Irregular menstrual cycles may increase the chance of pregnancy during menstruation; fertility varies, and tracking ovulation helps optimize conception.
    47:42 🗓 The most fertile time is the 5-day window ending on the day of ovulation; regular cycles help predict ovulation for optimal conception.
    49:07 💑 Higher estrogen levels increase libido, synchronizing with ovulation; estrogen triggers LH surge, enhancing the chances of conception.
    50:31 🩹 Some women can feel ovulation; it’s known as “mittelschmerz,” acrampy pain indicating the release of the egg.
    52:21 📅 Daily intercourse increases fertility, especially during the fertile window; every-other-day intercourse reduces stress without compromising success.
    56:30 🌿 Nicotine, cannabis, and alcohol can impact egg and sperm quality; moderation is crucial for those planning to conceive.
    01:05:46 🤰 Pregnancy is not health-neutral; one must be in good health to prevent complications.
    01:06:13 🩸 Progesterone-based IUDs thin the uterine lining, potentially causing absence of periods after removal.
    01:08:45 💉 Depo-Provera shot prevents ovulation for 3 months but can affect periods for up to 18 months after discontinuation.
    01:10:41 🔄 Oral contraception may impact women’s perception of facial attractiveness in men, as per a study.
    01:12:22 💊 Birth control pills have potential risks and benefits; they may impact vaginal health and clotting factors.
    01:15:08 🩸 Birth control pills can be beneficial for mental health, heavy periods, anemia, and conditions like PCOS.
    01:17:02 🚫 PCOS increases the risk of endometrial cancer due to lack of ovulation, and birth control pills can prevent this risk.
    01:18:14 🚫 Birth control pills may decrease the risk of ovarian cancer but could potentially increase the risk of breast cancer in some cases.
    01:20:30 🩸 Factor V Leiden mutation can be exacerbated by oral contraception, potentially leading to blood clots.
    01:24:37 🤔 Screening for Factor V Leiden is not a routine recommendation before prescribing birth control, but individuals with a family history of clotting issues should consider it.
    01:25:06 🩸 Screening for ovarian reserve, specifically AMH levels, is not routinely recommended by ACOG, but individuals can advocate for it. The cost is approximately $79.
    01:26:57 🥚 The number of eggs coming out of the vault is an indirect measure of the eggs inside, with a decline indicating a decrease in egg quantity.
    01:27:38 🩺 Antral follicle count (AFC) is an ultrasound-based measurement of eggs outside the vault. The expected range is 16-20 total follicles per month for a 30-year-old, decreasing with age.
    01:29:17 🔄 Follicle count drops significantly around age 37, leading to a severe decline after 37. Egg freezing becomes crucial for preserving fertility.
    01:30:13 🥚 Collecting eggs doesn’t change what’s in the vault; it provides an opportunity for potential pregnancies. Egg freezing’s success is influenced by factors like age, egg quality, and embryo development.
    01:37:17 🧬 Egg quality decreases with age, leading to a higher risk of genetic abnormalities and miscarriages. Embryo freezing has higher survival rates than freezing eggs but is more expensive.
    01:40:40 🕰 Fertility counseling involves informed consent on the likelihood of success based on age, egg count, and potential embryo formation. Age 37 is a critical point for considering fertility interventions.
    01:43:39 💉 The optimal time for egg freezing is around ages 32-33. The procedure involves hormone injections for egg stimulation, with potential variations in protocols. The decision should consider the future sperm source, health risks, and pain levels.
    01:46:36 🍼 Implanting one embryo at a time is standard in IVF, reducing the risk of monozygotic twinning. Success rates vary based on factors like age and embryo health, emphasizing the importance of multiple cycles for better chances.
    01:47:17 🍼 The outer surface of embryos touched during IVF may increase the chance of splitting, leading to a higher chance of monozygotic twins.
    01:48:12 💰 Embryo quality is a crucial aspect of fertility, and the cost of egg freezing and IVF makes it important not to waste embryos in the same uterine environment.
    01:49:18 🔄 Cumulative success rates for pregnancy increase with the number of euploid (genetically normal) embryo transfers, with 95% success after three transfers.
    01:50:25 🤔 Embryo freezing provides benefits, especially for partnered individuals, as it allows for better family planning and intervention based on the number and quality of embryos.
    01:51:32 🥚 Freezing sperm is recommended for men considering a vasectomy as a precautionary measure, providing flexibility in case of changing life circumstances.
    01:53:50 🚫 Getting a vasectomy without freezing sperm first may limit options for future family planning, and sperm freezing is a relatively easy and cost-effective procedure.
    01:55:10 🌐 Egg freezing and IVF involve a combination of hormonal medications, including FSH and LH, to stimulate follicle growth, followed by a trigger shot to allow final egg maturation.

  5. I have been following both for a long time; never did I expect a crossover episode, but it feels full circle as I’m nursing my six-month baby girl right now 😁😆🙌🏻

  6. Dr. Crawford is so well spoken. Shes so good at breaking things down and always bringing it to a point. im learning so much!😊

  7. Please, please do a full episode on Menopause. I think a big part of your audience will appreciate it 🙂 Thank you for all your work, I’m a big fan!

  8. Would it be possible to do an episode on oral health (teeth, gum,…)? I’m studying to become a dentist and it’s never stops to amaze me how many people do not realize how important oral health is for overall wellbeing.

    Thanks for your great work! I’m a longtime follower

  9. Yes, please do an episode on menopause. When I have talked to doctors about issues with menopause they haven’t been able to engage in a conversation that shows any kind of complete understanding of the issues or the therapies available. My grandmother died of ovarian cancer. My mother had endometriosis. I have always been afraid of hormone replacement, according to this it might be too late if it’s not dangerous for me. I could never find a doctor that could speak to it’s safety. So many issues come with menopause and this older stage of life.

  10. Thank you so much for having me and letting me talk about my passion! Also – had so much fun, we could talk for hours, let’s do it again!

  11. @FrejaHana – I believe that oral health is listed in…’The 12 pillars of health” – often brought up on various health, longevity, and
    ‘healthy aging’ podcasts.

    (Unsure who, i.e what agency developed this list? Pub Med? NIH? CDC?

    Not sure🙄 – but the ’12 pillars of Health’ gets mentioned alot (I just have never paid attention to where this compiled list originates from 🙄

    But, oral health is definitely one of the 12 pillars listed in this compilation. Heard it many times😊

  12. I have been looking forward to Huberman covering this topic for a long time. He has covered female hormone health briefly on other podcasts but not as in-deathly. I learned so much. If I have one critic is that whenever Dr. Crawford started to truly explain a subtopic of female health Huberman would ask a question about male hormones or sperm health, and I really wanted to hear what she was talking about regarding female health before Huberman redirected the flow of the conversation to talk about male health. Is it truly that hard to talk about female hormones and health without diverting to discuss male hormones and sperm?

  13. I would love an episode dedicated to perimenopause menopause and female hormone replacement therapy, what to do to decrease anxiety, depression, brain fog in women going through hormone changes, how to boost libido during this stage and what supplements one should take during pre-menopause and during menopause. And if there is any thing that can be done to delay the onset of menopause.

  14. Such a pleasure to host you Natalie! Thank you for the immense amount of valuable knowledge you so generously shared, and with such clarity, for the listeners. Would love to continue the conversation!
    Best wishes,
    Andrew

  15. After having a baby almost two years ago I am unable to get pregnant again. Based on my symptoms I suspect hormonal imbalance. Excited to listen to this episode and hoping to find some answers.
    Thank you for educating the public on such an important topic

  16. Yesss! And also
    🦷the pros/cons of root canal surgery vs pulling the tooth
    🌀TMJ treatment and its impact on hearing, sinuses, back/spine alignment

  17. One of the best episodes so far. So eye opening, extremelly well spoken and super important topic. Loking forward to further episodes diving deeper into PCOS, endomentriosis and cycle syncing for female health.

  18. your work is amazing, please have Dr. Lisa Mosconi to talk about women’s brain health and menopause

  19. I appreciate this episode first because I am a women and second these are such important topics for women. Peace be with you and blessings to @hubermanlab and @NatalieCrawfordMD. You are doing important, impactful work.

  20. Yes, please.
    I’m facing all of that soon and I’m definitely looking for all the information I can get!

  21. Enthralled is the perfect word ! Awesome episode! I wanted there to be some traffic to keep listening 😂

  22. PLEASE do a pregnancy and early postpartum podcast! It’s nearly impossible to find protocols or even suggestions of how and why to do or not do things in pregnancy. It feels like every awful thing about pregnancy is “normal” until “wait no that’s not normal you should’ve gone to the ER” I need someone to demystify pregnancy and postpartum!

  23. My grandmother had my mom (naturally) at age 50, I have never wanted children so I have always made sure that wouldn’t happen and I couldn’t wait to reach menopause myself so I could put it all behind me. That all said I feel like this episode is going to help so many people that choose to have children, you are really doing a kind service here 💜

  24. Hi Andrew! I loved this episode. *Please* have Dr. Crawford or another specialist on to talk about pregnancy! Optimal diet, exercise, avoiding harming the baby’s reproductive development, etc. Maybe even the labour/delivery and postpartum process as well.

    I just had my first baby and have been hoping for such a podcast from you. I figured maybe pregnancy was somewhat niche for your audience, but I realized it’s many women’s realities for maybe a decade of their lives. Not to mention the importance of ensuring the next generations are as healthy as they can be!

    Thank you. My husband and I love your podcast! Keep the good stuff coming 🙂

  25. I love how weird German words are always used to describe something that might not be easily described in one word in another language 😅 Mittelschmerz, basically just describes pain in the middle of something (time, place). Great podcast!

  26. Given the context of this whole discussion, when I read “given me a cup”, I automatically assumed it was to “deposit” sperm. Then I thought it was hilarious that such a cup says “What would Huberman do?” on it.

    This probably means @hubermanlab did a great job of creating engagement around this topic.

  27. When was this (what year)? I know a woman who conceived and delivered naturally at aged 46.

  28. I was a surrogate 3 times, ages 37,39, & 41. Currently 42. Had 3 of my own before that. What implecations will this have on me that may not have otherwise been concerning the hormones and manipulation done as part of the process? This episode jumped straight into my top 3 favorites before I even got halfway through! Love you both, love science.!!! Everyone needs to know these things!!! Thank you so much for all that you do to educate!

  29. Such an incredible episode! I loved the topic and craved a bit more information regarding nutrition and exercise and how that affects hormones. Personally, pregnancy and postpartum are so key in mental health and hormonal changes and I had no idea until I got pregnant with my first baby. It would be awesome to see an episode on those topics.

  30. Just finishing the entire podcast. It was so insightful! I hope there is a part 2; if so, could you guys touch on the subject of exercising during pregnancy?

    I am struggling with cooperating with my OBGYN’s orders of staying within a certain heart rate. It’s a much lower BPM than I normally train in and is difficult for me to maintain. (Just to give an idea, I’m a long distance runner who is currently finishing first trimester and entering into my second.)

    THANK YOU guys!

  31. Great suggestion, especially knowing the high rates of maternal deaths in the US. It’s all normal, work until you’re in labor, but let’s do a C-section since your baby’s heart rate is off (not to mention the longer hospital stay and higher $$$$$ from insurers).

  32. He is trying to predict the questions that would occur, especially knowing that a larger percentage of his audience is men. She also would have a very good idea of how sperm works, and knowing that pregnancy clearly requires a man and sperm – it is relevant.

  33. He is trying to predict the questions that would occur, especially knowing that a larger percentage of his audience is men. She also would have a very good idea of how sperm works, and knowing that pregnancy clearly requires a man and sperm – it is relevant.

  34. @@222dillon I will assume you are correct about the percentage of male to female viewers. However, I will also assume that Prof. H. Wants to have an appeal to females as well and not exclusively to males only. And he does indeed have a dedicated group of diehard female viewers. I can’t speak for all female viewers, but I love how Prof. H goes deep into the weeds sometimes on certain subjects and really breaks down the science and then explains the application. And to the most part that happened during this discussion. However, there were a few instances when the guest started really getting deep on an angle that is relevant to female anatomy and biology that Prof. H then paused her flow by directing her to discuss male sperm health. Any long time follower of Prof. H knows he has chapters. And as sperm health is relevant to those females who want to reproduce with a male, it is not relevant to all females. Thus, I wish he would have segmented the topic on male health and male sperm health to a chapter. That way the dedicated female viewers get a very deep and riveting conversation on female hormones and fertility and the females and males who are interested in sperm health can easily jump to the chapter that discusses that topic. This is a both and proposition not an either or. Both audiences get served, and in one of the few episodes specifically focusing on female health, that audience gets a fully vetted and deep dive conversation. Many of us females share his episodes with our family and friends who also happen to be female. So although he may not have that many female subscribers, individual episodes, when relevant to females, will be viewed by a higher percentage of females due to sharing. So going all in on the female perspective and application would be greatly appreciated. And I also acknowledge that a lot of females do want to know about male health and sperm health so that information is relevant and should be included. However, having it not take over the conversation about female hormone health would be good too. No hate here, just love.

  35. @@222dillon ​​⁠ I will assume you are correct about the percentage of male to female viewers. However, I will also assume that Prof. H. Wants to have an appeal to females as well and not exclusively to males only. And he does indeed have a dedicated group of diehard female viewers. I can’t speak for all female viewers, but I love how Prof. H goes deep into the weeds sometimes on certain subjects and really breaks down the science and then explains the application. And to the most part that happened during this discussion. However, there were a few instances when the guest started really getting deep on an angle that is relevant to female anatomy and biology that Prof. H then paused her flow by directing her to discuss male sperm health. Any long time follower of Prof. H knows he has chapters. And as sperm health is relevant to those females who want to reproduce with a male, it is not relevant to all females. Thus, I wish he would have segmented the topic on male health and male sperm health to a chapter. That way the dedicated female viewers get a very deep and riveting conversation on female hormones and fertility and the females and males who are interested in sperm health can easily jump to the chapter that discusses that topic. This is a both and proposition not an either or. Both audiences get served, and in one of the few episodes specifically focusing on female health, that audience gets a fully vetted and deep dive conversation. Many of us females share his episodes with our family and friends who also happen to be female. So although he may not have that many female subscribers, individual episodes, when relevant to females, will be viewed by a higher percentage of females due to sharing. So going all in on the female perspective and application would be greatly appreciated. And I also acknowledge that a lot of females do want to know about male health and sperm health so that information is relevant and should be included. However, having it not take over the conversation about female hormone health would be good too. No hate here, just love.

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